Author: Tony Zhang

Pholcodine, used as an over-the-counter cough suppressant in syrups and lozenges to manage cold symptoms, has now been withdrawn from the market by authorities including the EU, UK, US, Australia, and in Asian countries Malaysia and Singapore [1-3]. The recent market withdrawal was based on the publication of the ALPHO case-control study [4] assessing the relationship between pholcodine exposure and neuromuscular blocking agents (NMBAs) related anaphylaxis in France. The researchers mentioned that for any anaphylaxis reactions to happen, it requires prior exposure to the antigen to induce sensitisation. But many patients who react to NMBAs have never been exposed to…

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